|Awarded On||February 15, 2023|
|Title||Integrative modeling of spatially resolved multi-omics data to identify bladder cancer mucosal field effects|
|Award Mechanism||Individual Investigator Research Awards for Computational Biology|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Peng Wei|
Bladder cancer, the fourth most common cancer among U.S. men, causes significant morbidity and mortality in the United States and across the world. A better understanding of how bladder cancer initiates and progresses is critical to its prevention, early detection, and treatment. The field effect in cancer is a biological process in which early changes in microscopically normal tissues and cells initiate cancer and precede the development of microscopically recognizable precursor lesions and carcinoma. We have developed a whole-organ histologic and genomic mapping (WOHGM) approach to identify genes and biological pathways whose modifications are associated with the evolution of bladder cance...