Grant ID RP230166
Awarded On February 15, 2023
Title Integrative modeling of spatially resolved multi-omics data to identify bladder cancer mucosal field effects
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Computational Biology
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Peng Wei
Cancer Sites Bladder
Contracted Amount $1,199,994
Lay Summary

Bladder cancer, the fourth most common cancer among U.S. men, causes significant morbidity and mortality in the United States and across the world. A better understanding of how bladder cancer initiates and progresses is critical to its prevention, early detection, and treatment. The field effect in cancer is a biological process in which early changes in microscopically normal tissues and cells initiate cancer and precede the development of microscopically recognizable precursor lesions and carcinoma. We have developed a whole-organ histologic and genomic mapping (WOHGM) approach to identify genes and biological pathways whose modifications are associated with the evolution of bladder cance...

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