|Awarded On||February 15, 2023|
|Title||Normalizing membrane homeostasis in microglia/macrophages of pediatric high-grade gliomas|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Jian Hu|
|Cancer Sites||Brain and Other Nervous System|
Pediatric brain tumors are the most common solid tumors in children, with 5,000 new cases diagnosed per year in the United States. Around 17% of brain tumors in children age 0-14 years are pediatric high-grade gliomas (pHGGs). pHGG is the deadliest cancer in children, with the median survival time of only 12-15 months despite aggressive therapy. pHGGs show distinct features from their adult counterpart (adult high-grade gliomas), and no new therapy for the disease has been developed for over 3 decades. Various high frequent mutations have been discovered in pHGGs, which potentially could be recognized by the immune system. However, the immune system in those patients has been disabled by a u...