|Awarded On||February 15, 2023|
|Title||Blocking DNA damage response induction of "don't eat me" signals converts local radiotherapy into systemic immunotherapy|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Michael Curran|
|Cancer Sites||Colorectal, Lung and Bronchus|
Radiotherapy (RT) is an established pillar of oncology employed to treat nearly half of all cancer patients at some stage of their therapy. While the role of the immune system in mediating both improved local responses, as well as the rarely observed systemic responses to radiation has been appreciated for decades, the underlying mechanisms governing the efficiency of immune mobilization in this context remain poorly defined. We recently showed that the response to radiation-induced DNA damage in cancer cells triggers upregulation of anti-phagocytosis checkpoints, which act to prevent tumor antigen cross-presentation and downstream activation of T cells which could otherwise mediate systemic...