|Awarded On||February 15, 2023|
|Title||Autophagy and Tumor Endothelium|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Lance S Terada|
|Cancer Sites||All Sites|
Cancerous tumors contain a complex mixture of different cell types including not only the culprit cancer cells but also normal tissue and immune cells. Called stromal cells, these are otherwise normal cells called in to perform abnormal functions, providing nutritional and structural support and immunologic protection of the resident cancer cells. Without the help of these supporting cells, tumors cannot progress. Few treatment regimens target these genetically normal cells, which, unlike cancer cells, cannot rely on mutations to escape targeted treatment regimens. Endothelial cells, which form new blood vessels that serve tumors, are an example of stromal cells that take on abnormal fun...