Grant ID RP230063
Awarded On February 15, 2023
Title Whole Genome DNA Methylation Markers for Tracking and Predicting Advanced Liver Fibrosis as a Precursor of Liver Cancer in NAFLD.
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Prevention and Early Detection
Institution/Organization Texas A&M University System Health Science Center
Principal Investigator/Program Director Robert Tsai
Cancer Sites Gallbladder, Liver and Intrahepatic Bile Duct
Contracted Amount $2,000,000
Lay Summary

There is a disproportionately high number of liver cancer patients in the Mexican American population in south Texas due to a high prevalence of fatty liver diseases, which affect 1 in 5 adults in Texas and 1 in 3 of its Hispanic population. Individuals with fatty liver are at risk for progressing to liver cancer through an intermediary step of liver fibrosis. The existence of a large liver cancer at-risk population in Texas provides an opportunity to develop and implement strategies to prevent liver cancer that will have major health impacts. There is an unmet need for new screening tools that are easily applicable in the clinic and capable of identifying individuals with fatty liver diseas...

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