Grant ID RP230026
Awarded On February 15, 2023
Title Identifying Clinical Methotrexate Toxicity Phenotypes Across Phases of Pediatric Leukemia Therapy
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Austin L Brown
Cancer Sites Leukemia
Contracted Amount $1,392,407
Lay Summary

Latino children are more likely to be diagnosed with acute lymphoblastic leukemia (ALL) compared to non-Latino children and more likely to have high risk disease, experience a relapse, or die due to leukemia. Sadly, this is even more apparent in Texas and across the Southwestern United States, where most newly diagnosed patients with ALL are Latino. Latino children are also more likely to have severe side effects from medicines used to treat ALL. At Texas Children's Cancer Center, we found that Latino children are more likely to have severe side effects from methotrexate, one of the most important medicines to treat ALL. If a patient has severe side effects, the pediatric oncologist may need...

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