Grant ID RP220666
Awarded On September 14, 2022
Title Targeting Tumors and the Tumor Microenvironment with Banana Lectin Expressing T cells
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Katie McKenna
Cancer Sites Lung and Bronchus
Contracted Amount $250,000*

*Pending contract negotiation

Lay Summary

Recent developments in the treatment of blood cancers with a genetically enhanced cell therapy called CAR T cells have improved patient outcomes. Unfortunately, those same therapies have not had the same success for solid cancers, which are much more common. Here we propose therapies to target not only the cancer cells in solid tumors but also the normal cells surrounding the cancer cells that act as their support structure and help the tumor grow. These surrounding cells also protect the tumor from the immune system and prevent some treatments from reaching and killing the cancer cells. By targeting both cell types, our proposed therapy should increase anti-tumor activity of drugs and cell ...

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