Grant ID RP220650
Awarded On September 14, 2022
Title Targeting Nitric Oxide Synthase (NOS) pathway to remodel obesity induced tumor inflammation in patients with TNBC
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The Methodist Hospital Research Institute
Principal Investigator/Program Director Jenny Chang
Cancer Sites Breast
Contracted Amount $250,000
Lay Summary

Obesity is a major health concern and contributes to various diseases including breast cancer. Triple-negative breast cancer (TNBC) is an aggressive and highly lethal subtype of breast cancer. Obese TNBC patients often have the worse outcome with a higher chance of resistance to traditional chemotherapy and increased risk of tumor recurrence. While the mechanism responsible for this outcome is unknown, evidence indicates its association with chronic inflammation. One of the inflammatory pathways being studied by our group is the nitric oxide synthases (NOS) pathway. We and others have shown that increased nitric oxide levels alter the tumor immune cell profile that lead to increased breast c...

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