|Awarded On||February 16, 2022|
|Title||Identification of oncogenic mechanisms driving lung squamous cell carcinoma development and progression|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Pawel Mazur|
|Cancer Sites||Lung and Bronchus|
Lung cancer is the leading cause of cancer death. In 2020, an estimated 10,792 Texas died of lung cancer that is more than due to the next three leading cancer types: colon (4,278), breast (3,254), and prostate (2,165) combined (Texas Department of State). The two most commonly diagnosed types of lung malignancies are lung adenocarcinoma and lung squamous cell cancer (LUSC) accounting for approximately 40% and 30% of all cases, respectively. However, unlike for lung adenocarcinoma, for which multiple targeted therapies are available, no targeted therapies are currently clinically available for LUSC. This has led to a tremendous disparity in the way in which patients with advanced lung cancer...