Grant ID RP220364
Awarded On February 16, 2022
Title KRAS mutation-induced KDM5D upregulation promotes male-specific colorectal cancer metastasis
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Ronald DePinho
Cancer Sites Colorectal
Contracted Amount $1,049,997
Lay Summary

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the US. Moreover, the metastasis and mortality rates are strikingly higher in men than in women. Intriguingly, these gender differences in CRC are observed only in tumors that have a KRAS mutated (KRAS*) gene. The molecular basis for these gender differences is not known.

In our mouse model of KRAS* CRC, these gender differences are also observed, providing a genetic model with which to study the mechanisms underlying how KRAS* may regulate higher metastasis and poorer survival in males. Our preliminary data have uncovered that KRAS* activates STAT4 which directly up-regulates the level of a Y chromosome-linked d...

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