|Awarded On||February 16, 2022|
|Title||Epigenetic regulation of alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Jian Hu|
|Cancer Sites||Brain and Other Nervous System|
Pediatric brain tumors are the most common solid tumors in children, with 5,000 new cases diagnosed per year in the United States. Around 17% of brain tumors in children age 0-14 years are pediatric high-grade gliomas (pHGGs). pHGG is the deadliest cancer in children, with the median survival time of only 12-15 months despite aggressive therapy. pHGGs show distinct features from their adult counterpart (adult high-grade gliomas), and no new therapy for the disease has been developed for over 3 decades. Therefore, the major problem we would like to tackle is to design mechanism-based therapies based on the onco-genomic features of pHGGs. Various high frequent mutations have been discovered in...