|Awarded On||February 16, 2022|
|Title||Understanding Rewired Intracellular Metabolism in Acute Myeloid Leukemia|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Jian Xu|
Acute myeloid leukemia (AML) is the deadliest blood cancer characterized by aberrant proliferation of hematopoietic precursor cells. Disease-causing leukemia stem cells (LSCs) acquire metabolic adaptations to initiate transformation and/or promote growth of cancer cells.
These metabolic alterations has been exploited to diagnose, monitor, and treat cancer; however, successful targeting of rewired cancer metabolism is rare for most cancers including AML. The challenge is two-fold: 1) to identify LSC-specific metabolic dependencies, and 2) to develop effective strategies to therapeutically target LSCs without affecting normal cells. During the prior award, we discovered that aberrant activatio...