Grant ID RP220330
Awarded On February 16, 2022
Title Decoding Bromodomain Chromatin Reader Protein Mechanisms in DNA repair and Replication - Implications for Cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas at Austin
Principal Investigator/Program Director Kyle Miller
Cancer Sites All Sites
Contracted Amount $1,050,000
Lay Summary

Cancer is a genetic disease caused by mutations in DNA, the material that stores our genetic information. Accessing this information correctly is essential for human health and relies on proteins that interact with and regulate chromatin, the organizational hubs of the genome. DNA within each of our cells is damaged thousands of times per hour per day, which can lead to mutations, decreased genome integrity and ultimately cancer. We have discovered that a large family of human proteins called bromodomain (BRD) proteins, which connect chromatin to DNA processes, are genome protectors and suppressors of DNA damage and cancer.

Understanding the basic biology of these proteins is essential for g...

Read More