|Awarded On||February 16, 2022|
|Title||Decoding Bromodomain Chromatin Reader Protein Mechanisms in DNA repair and Replication - Implications for Cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas at Austin|
|Principal Investigator/Program Director||Kyle Miller|
|Cancer Sites||All Sites|
Cancer is a genetic disease caused by mutations in DNA, the material that stores our genetic information. Accessing this information correctly is essential for human health and relies on proteins that interact with and regulate chromatin, the organizational hubs of the genome. DNA within each of our cells is damaged thousands of times per hour per day, which can lead to mutations, decreased genome integrity and ultimately cancer. We have discovered that a large family of human proteins called bromodomain (BRD) proteins, which connect chromatin to DNA processes, are genome protectors and suppressors of DNA damage and cancer.
Understanding the basic biology of these proteins is essential for g...