Grant ID RP220312
Awarded On February 16, 2022
Title Interrogating and targeting altered cellular metabolism in Hürthle cell carcinoma of the thyroid
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director David G McFadden
Cancer Sites Thyroid
Contracted Amount $858,315
Lay Summary

Cancer cells must change their metabolism to support the growth and spread of the tumor. Mitochondria, the "power plants of the cell", produce most of the energy used by normal cells. It is becoming clear that most cancers depend on the mitochondria to promote the growth and division of the tumor cells.

The McFadden lab is studying a form of thyroid cancer called Hürthle cell carcinoma in which the mitochondria are defective due to mutations in the DNA within the mitochondria. Hürthle call cancers are a clinical challenge with few treatment options. The McFadden lab has used a laboratory model in which a tumor from a patient with Hurthle carcinoma was grown in mice and then used to...

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