Grant ID RP220309
Awarded On February 16, 2022
Title The role of ribosomal RNA modification in oncogene-induced senescence and tumorigenesis
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Joshua Mendell
Cancer Sites Lung and Bronchus
Contracted Amount $1,050,000
Lay Summary

Approximately 50 years ago, it was discovered that normal human cells can only undergo a finite number of divisions before they stop dividing and enter a quiescent state known as senescence. Surprisingly, it was later shown that mutations that activate genes that promote cancer development, known as oncogenes, can also cause cells to enter a senescent state. This phenomenon of so-called "oncogene-induced senescence" is a major protective mechanism that suppresses cancer formation by preventing cells with mutated oncogenes from expanding and forming tumors. In most human malignancies, cells acquire other mutations that allow them to bypass this senescent state and proliferate in an uncontr...

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