Grant ID RP220270
Awarded On February 16, 2022
Title Developing Imaging Biomarkers for Immunotherapy Resistance In Vivo
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Pratip Bhattacharya
Cancer Sites Skin
Contracted Amount $1,050,000
Lay Summary

Despite remarkable progress in immunotherapy, definitive biomarkers which can accurately predict clinical response to immunotherapy are still lacking. Resistance to immunotherapy can be largely attributed to extracellular acidity in the tumor microenvironment. We propose to reduce the acidity to improve the response to immunotherapy. We propose to inhibit Vacuolar ATPase that pumps acid out of the tumor cell; Monocarboxylate Transporter 1 that secretes lactic acid into the tumor microenvironment; and Carbonic Anhydrase IX that neutralizes intracellular acids and causes extracellular acidity. We refer to the use of one or more of these inhibitors as "pH-sensitizers" for immunotherapy. We will...

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