Grant ID RP220269
Awarded On February 16, 2022
Title MiR223-3p Suppression of BRCA1-Mutant Oncogenesis
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Robert Hromas
Cancer Sites Breast, Ovary
Contracted Amount $889,587
Lay Summary

All cells, including cancers, must replicate their DNA to divide. DNA replication is not a smooth process, but one filled with stops that must be overcome. The preferred pathway to restart DNA replication is called homologous recombination (HR), which preserves the genetic code. There is a back-up restart pathway called alternative non-homologous end joining (aNHEJ), but this pathway does not always preserve genetic information and can cause chromosomal abnormalities called translocations. These chromosomal translocations can lead to cell death, cell aging, or transformation to malignancy.

Normal cells express a small RNA segment termed miR223-3p that represses aNHEJ and promotes HR. When a...

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