|Awarded On||February 16, 2022|
|Title||Study AMPK in ferroptosis regulation: mechanisms and preclinical translation|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Boyi Gan|
|Cancer Sites||Lung and Bronchus|
Cell death resistance is a hallmark of cancer. Many cancer therapies are designed to induce apoptosis, the best-known cell death mechanism, in cancer cells. However, in many cases, cancer therapies are ineffective in inducing apoptosis during cancer treatment partly due to genetic alterations of apoptotic pathways in human cancers, leading to therapy resistance and tumor recurrence. Thus, studying mechanisms of alternative regulated cell death may provide novel strategies in cancer treatment.
Ferroptosis is an iron-dependent form of nonapoptotic cell death that is induced by a type of lipid damage on cellular membranes called lipid peroxidation. Certain drugs known as ferroptosis inducers c...