Grant ID RP220235
Awarded On February 16, 2022
Title Dual function of the PRC2 complex in medulloblastoma development
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Jiang Wu
Cancer Sites Brain and Other Nervous System
Contracted Amount $1,399,996
Lay Summary

Tumor cells are often heterogeneous and contain subclones with genetic and epigenetic variations. One frontier of cancer study is how cancer subclones compete and cooperate during cancer development. Medulloblastomas (MB), the most common childhood malignant brain tumor, are highly heterogeneous between different tumors and within a single tumor, which complicates treatment options. Sonic hedgehog (SHH) type MBs compose 25% of all MBs and are characterized by elevated SHH signaling and a cerebellum granule neuron precursor (CGNP) cell-of-origin.

One important characteristic of MB is its significant association with epigenetic abnormalities, including those in the H3K27me3 methyltransferase P...

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