Grant ID RP220208
Awarded On February 16, 2022
Title Targeting SMARCA4 Mutations in Pediatric Burkitt Lymphoma
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Michael Green
Cancer Sites Lymphoma
Contracted Amount $1,400,000
Lay Summary

Pediatric Burkitt lymphoma (pBL) is the most frequent pediatric lymphoma and has a median onset of 10 years old. Although a large fraction of patients can be cured with high-dose combination chemotherapy, long-term survivors often suffer from treatment-associated morbidity and those that relapse have dismal outcomes.

This highlights a need for better understanding of disease mechanisms so that we can design more effective and less toxic therapies. The cell of origin for pBL arises from B-cells that are undergoing a natural process of proliferation and mutation in response to an antigen, within a microphysiological structure called the germinal center (GC). Under normal circumstances, develo...

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