Grant ID RP220101
Awarded On February 16, 2022
Title Single-cell decoding of spatiotemporal and ecological evolution in early-stage KRAS- mutant lung cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Humam Kadara
Cancer Sites Lung and Bronchus
Contracted Amount $831,561
Lay Summary

A large fraction of lung cancers contains genetic changes (called mutations) in a tumor promoting gene called KRAS. KRAS-mutant lung cancer, often very aggressive and notoriously difficult to treat, is the most common lung malignancy diagnosed in current or former smokers and the epidemic of this lethal disease will remain long after smoking incidence has dropped. It is widely appreciated that carcinogenic (such as smoking) exposure elicits tumor promoting molecular and inflammatory changes throughout the lung. Notably, the lung is ecologically rich with various cell populations besides the airway lining including diverse immune subsets that may participate in cancer. Yet, for a fatal malign...

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