Grant ID RP220050
Awarded On February 16, 2022
Title Signaling network modeling to identify new treatments for triple-negative breast cancer
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Computational Biology
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Bing Zhang
Cancer Sites Breast
Contracted Amount $1,200,000
Lay Summary

Triple-negative breast cancer (TNBC) is a deadly disease accounting for 15-20% of the annual new cases of invasive breast cancer in the U.S. Genomic characterization of TNBC has not identified therapeutically targetable, high-frequency "driver" alterations, which has impeded development of molecularly targeted therapies. Most TNBC patients are treated with cytotoxic chemotherapy regimens with only marginal success. Kinases are frequently dysregulated in human cancer and are attractive targets for therapeutic intervention. Recent advancements in mass spectrometry (MS)-based proteomics allow unbiased characterization of proteins and their modifications in clinical tumor specimens, providing ne...

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