Grant ID RP220046
Awarded On February 16, 2022
Title Dissect and disable altered tryptophan metabolism in MYC-driven tumors
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Maralice Conacci-Sorrell
Cancer Sites Gallbladder, Liver and Intrahepatic Bile Duct
Contracted Amount $1,049,997
Lay Summary

Liver cancer is the third leading cause of cancer mortality worldwide. Excessive alcohol consumption, viral hepatitis, metabolic syndrome, and obesity are major causes of liver damage. Liver damage can progress to fatty liver disease, fibrosis, and cirrhosis, which dramatically increase the risk of cancer. Likely due to these environmental factors, the incidence of liver cancer in the United States has tripled in the last decades; however, the overall survival rates of patients with liver cancer have remained low.

Our work focuses on a simple question: What do cancer cells need to grow? To answer this question, we are focused on identifying the specific nutritional needs of cancer cells tha...

Read More