Grant ID RP220032
Awarded On February 16, 2022
Title Targeting immunosuppressive myeloid cells in tumor microenvironment
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Chengcheng Zhang
Cancer Sites Breast, Ovary, Skin
Contracted Amount $1,049,997
Lay Summary

PD-1 and CTLA-4 immunotherapies have been successful in treating some types of cancers but not others. These therapies target molecules on one immune cell type - T cells - to activate dysfunctional T cells that are suppressed by tumors. Nevertheless, other types of immune cells, in particular myeloid cells, are present around the tumors in much larger numbers than T cells. The roles of these myeloid cells in cancer development are not well defined. A better understanding of the function of these myeloid cells in cancer immunology will support development of novel therapeutic strategies for cancer treatment.

We found that LILRB3, a protein present on the surface of human myeloid cells supp...

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