|Awarded On||February 16, 2022|
|Title||Monitoring of Field Effects for the Detection of Bladder Cancer|
|Award Mechanism||Individual Investigator Research Awards for Prevention and Early Detection|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Bogdan Czerniak|
In this grant we propose whole-organ-based genomic characterization of field effects and how they evolve to clinically aggressive bladder cancer complemented by the validation studies of novel multi-colored Quartet FISH and voided urine exome sequencing. These studies will provide novel markers for diagnostic monitoring of bladder cancer including its recurrence and progression by a non-invasive approach in voided urine. When completed these studies will positively impact the clinical practice and management of patients affected by this common cancer.