Grant ID RP210236
Awarded On August 18, 2021
Title Magnetomechanical modulation of blood-brain barrier permeability
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas at Dallas
Principal Investigator/Program Director Zhenpeng Qin
Cancer Sites Brain and Other Nervous System
Contracted Amount $250,000
Lay Summary

Glioblastoma, the most common adult brain tumor, is among the deadliest of all solid tumors with a median survival of 14.6 months. This status has not changed for over ten years despite intense therapeutic efforts. A unique and major challenge in treating brain tumors is difficulty in delivering effective drugs across the blood-brain barrier (BBB), which protects the brain by preventing many substances in the blood from entering the brain tissue. Our long-term goal is to develop a strategy to temporarily increase BBB permeability and allow effective delivery of anti-cancer drugs without causing additional damage to the brain. This project aims to design and produce magnetic nanoparticles th...

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