|Awarded On||August 18, 2021|
|Title||Proteomics and Metabolomics Core Facility|
|Award Mechanism||Core Facility Support Awards|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Dean P Edwards|
|Cancer Sites||All Sites|
Cancer is a complex disease where a few genetic mutations can start a program of uncontrolled cellular growth. While mutations define cancer predisposition, the proteins are responsible for setting and sustaining energy metabolism in developing tumors, evading the immune response, and allowing escape of organ boundaries to establish metastases throughout the body. No cancer has been completely cured by fixing an originating gene mutation - the therapeutics have to target evolving oncogenic alterations in proteomic and metabolomic processes. It is now clear that only comprehensive proteogenomic and metabolomic characterization of individual tumors could fully explain why some drugs will prove...