Grant ID RP210227
Awarded On August 18, 2021
Title Proteomics and Metabolomics Core Facility
Program Academic Research
Award Mechanism Core Facility Support Awards
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Dean P Edwards
Cancer Sites All Sites
Contracted Amount $3,977,681
Lay Summary

Cancer is a complex disease where a few genetic mutations can start a program of uncontrolled cellular growth. While mutations define cancer predisposition, the proteins are responsible for setting and sustaining energy metabolism in developing tumors, evading the immune response, and allowing escape of organ boundaries to establish metastases throughout the body. No cancer has been completely cured by fixing an originating gene mutation - the therapeutics have to target evolving oncogenic alterations in proteomic and metabolomic processes. It is now clear that only comprehensive proteogenomic and metabolomic characterization of individual tumors could fully explain why some drugs will prove...

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