Grant ID RP210199
Awarded On August 18, 2021
Title Treating Metastatic Cancer using Microbubble-assisted Ultrasound-guided Immunotherapy of Cancer of Cancer (MUSIC)
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Jacques Lux
Cancer Sites All Sites
Contracted Amount $249,011
Lay Summary

Despite advances in the treatment of locally advanced cancers, patients with metastatic cancer often develop treatment resistance and succumb to the disease. Therefore, identifying new and effective treatment options for metastatic cancer is a major challenge and unmet clinical need. Cancer immunotherapy that targets the adaptive immune system such as immune checkpoint blockers has recently emerged as a revolutionary treatment for metastatic cancers. However, only a small subpopulation of patients benefits from immune checkpoint inhibitor treatment. There is now a realization that to improve the response rate of cancer patients to immunotherapy, stimulation of the innate immune system is al...

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