Grant ID RP210158
Awarded On August 18, 2021
Title Improving CAR T-cell therapy of T-ALL by co-targeting additional antigens
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Maksim Mamonkin
Cancer Sites Leukemia, Lymphoma
Contracted Amount $250,000
Lay Summary

Patients with B-cell leukemia can benefit tremendously from the latest generation of targeted cellular immunotherapies where their own killer cells (called T-cells) are engineered with special molecules called chimeric antigen receptors (CARs) which recognize and kill tumor cells. In stark contrast, patients with T-cell leukemia (T-ALL) lack any options for those life-saving treatments and mostly have to rely on conventional chemotherapies, which can be toxic and not always effective. Developing CAR T-cell therapies for patients with T-ALL is very challenging because the protein targets that the CARs can recognize are often present on vital tissues, including T-cells themselves. This can lea...

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