Grant ID RP210148
Awarded On August 18, 2021
Title Novel pharmacodynamic assay to predict response to CDK4/6 inhibitor therapy
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization University of Houston
Principal Investigator/Program Director Meghana Trivedi
Cancer Sites Breast
Contracted Amount $250,000
Lay Summary

Novel targeted therapies have provided advantage in extending survival in cancer patients. However, these therapies do not benefit all patients. They also have severe toxicities and high costs. Inappropriate selection of first- or second-line therapies can drastically limit the long-term survival especially in patients with metastatic disease. One such novel targeted therapy is the class of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i’s). Three agents (palbociclib, ribociclib, abemaciclib) are approved by the FDA in hormone receptor-positive, human epidermal growth factor receptor-2-negative (HR+/HER2-) metastatic breast cancer. They improve survival when combined with standard endocrine ...

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