Grant ID RP210144
Awarded On August 18, 2021
Title Leveraging glioma stem cell electrophysiology for therapy
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The Methodist Hospital Research Institute
Principal Investigator/Program Director Robert Rostomily
Cancer Sites Brain and Other Nervous System
Contracted Amount $248,028
Lay Summary

The most common adult brain cancer, glioblastoma (GBM) is incurable. Average survivals of 16-20 months have not improved significantly in decades underscoring the need for new approaches to therapy. The GBM stem cell (GSC) is a unique cell type within GBMs that is inherently resistant to treatments. In addition, heterogeneous mutations drive selection for treatment resistant GSC sub-populations within a tumor that drive progression. Here we propose a new strategy targeting GSCs based on leveraging their generic properties essential for maintaining their “identity” and malignant behavior. One such property, with great therapeutic potential, is the GSC cell membrane voltage potential, or ...

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