Grant ID RP210111
Awarded On August 18, 2021
Title Single-cell proteomics to dissect intra-tumor heterogeneity
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Health Science Center at Houston
Principal Investigator/Program Director Sheng Pan
Cancer Sites All Sites
Contracted Amount $250,000
Lay Summary

Direct measurement of unique constellations of proteins produced by single cells promises to expand our understanding of molecular cell-to-cell differences (heterogeneity) and their contribution to cellular functions in both disease and health. Mass spectrometry (MS) based single-cell proteomics represents an emerging technology for system wide, unbiased profiling of proteins in single cells or single cell clusters. Recent advances in nanoscale sample collection and processing, separation, and ionization have extended this powerful technology to meet many pressing medical challenges, such as diagnosing disease, enhancing directed stem cell differentiation, and classifying cancers. With the r...

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