Grant ID RP210079
Awarded On August 18, 2021
Title Targeting Mitochondrial NAD+ in Leukemias
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas at Austin
Principal Investigator/Program Director Xiaolu Cambronne
Cancer Sites Leukemia
Contracted Amount $250,000
Lay Summary

My group recently discovered a new protein called SLC25A51 that controls how all human cells harness energy through metabolic pathways in the mitochondria. One of the biggest challenges in acute myeloid leukemia is that most patients relapse in less than five years, and so there is a need to identify new therapeutic targets. Intriguingly, this type of cancer requires a metabolism that is directly controlled by SLC25A51 to survive. We propose that blocking the activity of SLC25A51 could advantageously target and exploit a unique vulnerability in leukemic cells. We will determine whether block of SLC25A51 stops the expansion of the cancer, as well as optimize a test we developed to identify co...

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