Grant ID RP210073
Awarded On August 18, 2021
Title Identification of collateral lethal and synthetic lethal targets in pancreatic and colorectal cancers
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Ronald DePinho
Cancer Sites Colorectal, Pancreas
Contracted Amount $249,994
Lay Summary

Pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC) are among the leading cancer killers with 47,000 deaths from PDAC and 53,000 deaths from metastatic CRC estimated in US 2020. PDAC and CRC genomes frequently contain deletions of tumor suppressor genes, including SMAD4 which is deleted in nearly 33% of PDAC cases and 10% of advanced CRC. When cancer cells sustain deletion of SMAD4, nearby genes that may play essential cell functions are invariably co-deleted. Cancer cells survive these co-deletions due to the presence of functionally redundant family members (known as paralogs) which reside elsewhere in the genome. We hypothesized that inhibiting the non-deleted paralogs can...

Read More