Grant ID RP210070
Awarded On August 18, 2021
Title Tunable epigenetic remodeling to modulate CAR T-cell based immunotherapy
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Texas A&M University System Health Science Center
Principal Investigator/Program Director Yubin Zhou
Cancer Sites Leukemia, Lymphoma, Skin
Contracted Amount $250,000
Lay Summary

This project is tightly aligned with the CPRIT mission to find a cure for cancer in order to save lives and prevent cancer. The goal of the proposed work is to engineer smart therapeutic T cells to advance precision medicine by delivering durable and controllable cell-based immunotherapy against cancer. Over the past five years, chimeric antigen receptor (CAR) T-cell based immunotherapy, also regarded as “living drugs” in the body, has achieved miraculous outcomes in certain patients with lymphoma and leukemia. Nonetheless, CAR T-cell therapy still faces challenges, partially because of severe side effects and its inability to last long-term therapeutic effects in some cancer patients. B...

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