Grant ID RP210068
Awarded On August 18, 2021
Title Role of Aberrant Translational Quality Control in Tumorigenesis of Glioblastoma
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Southern Methodist University
Principal Investigator/Program Director Zhihao Wu
Cancer Sites Brain and Other Nervous System
Contracted Amount $249,272
Lay Summary

Mitochondria are the cellular organs that generate energy using oxygen. Glioblastoma (GBM) is aggressive cancer without a cure. Due to their rapid proliferation, GBM cells need to adapt to a low oxygen environment. They do so by altering normal mitochondrial functions. One adaptation is an increased concentration of proton outside the inner mitochondrial membrane, referred to as high membrane potential, which has been shown to be critical for tumor growth. Therefore, reducing mitochondrial membrane potential may be a promising novel approach to treat GBM. However, it is unclear how GBM maintains a higher than normal mitochondrial membrane potential which normally is generated by concentratin...

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