|Awarded On||August 19, 2020|
|Title||Screening for Melanoma Genes Using Natural Hybrid Incompatibilities|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas State University|
|Principal Investigator/Program Director||Manfred Schartl|
*Pending contract negotiation
This proposal will use an innovative approach to identify previously unknown genes involved in melanoma progression that are potentially important for personalized therapies. Melanoma is the most aggressive form of skin cancer and impacts 1 in 50 Americans. Moreover, melanoma is one of the only cancers whose incidence has increased in recent years, showing a 6-fold increase in diagnosed cases over the past 40 years, with especially high risk in young men. Developing effective treatments for melanoma starts with understanding its underlying genetic causes. Recent efforts have identified common genetic mutations that drive the formation of cancers. However, individual patients with the same ge...