Grant ID RP200655
Awarded On August 19, 2020
Title A Novel Organoid Platform to Modulate Human Neural Networks Integrated with Glioblastoma Stem Cells
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The Methodist Hospital Research Institute
Principal Investigator/Program Director Robert Krencik
Cancer Sites Brain and Other Nervous System
Contracted Amount $249,372
Lay Summary

Our goal is to establish a new and well-defined experimental human-derived cellular tool that can serve as a drug testing platform for brain cancers, including glioblastoma. This tool will consist of patient-derived glioblastoma stem cells systematically incorporated within human neural cells that are rapidly derived from pluripotent stem cells. We will also incorporate a method to pace neural activity within the platform which will enable modeling of human brain activity. The significance of this project is that it is expected to provide a new drug testing platform that is a better recapitulation of the brain environment as compared to existing technologies and, thus, it will accelerate the...

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