Grant ID RP200650
Awarded On August 19, 2020
Title Characterization of Salmonella Tumor Targeting Mechanisms and Oncolytic Potential
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Medical Branch at Galveston
Principal Investigator/Program Director Linda Kenney
Cancer Sites Pancreas
Contracted Amount $250,000
Lay Summary

Cancer chemotherapies suffer from the development of drug resistance and a lack of specificity of treatments. In particular, pancreatic cancer mortality rates remain high, with a low probability of long-term survival and is thus the focus of the current proposal. Spontaneous tumor regression following a severe microbial infection was observed over 150 years ago and inspired some of the earliest cancer therapies. Evidently, a bacterial infection in a cancer patient stimulates the immune system to trigger robust anti-tumor immunity in the otherwise immune-suppressive tumor microenvironment. Salmonella has emerged as an ideal therapeutic candidate due to its intrinsic tumor targeting ability an...

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