|Awarded On||August 19, 2020|
|Title||Characterization of Salmonella Tumor Targeting Mechanisms and Oncolytic Potential|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Medical Branch at Galveston|
|Principal Investigator/Program Director||Linda Kenney|
Cancer chemotherapies suffer from the development of drug resistance and a lack of specificity of treatments. In particular, pancreatic cancer mortality rates remain high, with a low probability of long-term survival and is thus the focus of the current proposal. Spontaneous tumor regression following a severe microbial infection was observed over 150 years ago and inspired some of the earliest cancer therapies. Evidently, a bacterial infection in a cancer patient stimulates the immune system to trigger robust anti-tumor immunity in the otherwise immune-suppressive tumor microenvironment. Salmonella has emerged as an ideal therapeutic candidate due to its intrinsic tumor targeting ability an...