Grant ID RP200549
Awarded On August 19, 2020
Title CPRIT Early Clinical Investigator Award
Program Academic Research
Award Mechanism Early Clinical Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director David Hsieh
Cancer Sites Gallbladder, Liver and Intrahepatic Bile Duct
Contracted Amount $1,499,998
Lay Summary

Goal 1: Reduce mortality of patients with advanced hepatocellular carcinoma (HCC) by testing a novel strategy of increasing cancer immunogenicity to enhance the activity of immune checkpoint inhibitors. Objective 1: Assess the response rate (primary endpoint) of combining two clinical drugs with known safety profiles including a splicing modulator, E7820, and a checkpoint inhibitor, pembrolizumab, in a phase II trial in patients with advanced HCC. Objective 2: Assess the overall survival, progression free survival, duration of response, and safety (secondary endpoints) of combination immunotherapy. Goal 2: Develop pharmacodynamic markers and elucidate mechanisms of resistance to E7820 and...

Read More