Grant ID RP200504
Awarded On August 19, 2020
Title Comprehensive Cancer Epigenomics Core Facility
Program Academic Research
Award Mechanism Core Facility Support Awards
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Rui Chen
Cancer Sites All Sites
Contracted Amount $3,999,943
Lay Summary

Cancer research has mostly been focused on mutations in DNA, both in somatic and germline cells. It is now realized that cancer progression, malignant transformation, and metastasis involve epigenetic abnormalities as well as genetic alterations. Epigenetics is the field of study of factors that interact with DNA that can change the expression of genes without mutations or alterations in the DNA sequence itself. In addition, cell-to-cell heterogeneity is a hallmark of cancer and hence characterizing and understanding the epigenetic signatures of cancer cells compared to normal cells at the single-cell level is crucial. Furthermore, the reversible nature of epigenetic alterations provides opp...

Read More