|Awarded On||August 19, 2020|
|Title||Comprehensive Cancer Epigenomics Core Facility|
|Award Mechanism||Core Facility Support Awards|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Rui Chen|
|Cancer Sites||All Sites|
Cancer research has mostly been focused on mutations in DNA, both in somatic and germline cells. It is now realized that cancer progression, malignant transformation, and metastasis involve epigenetic abnormalities as well as genetic alterations. Epigenetics is the field of study of factors that interact with DNA that can change the expression of genes without mutations or alterations in the DNA sequence itself. In addition, cell-to-cell heterogeneity is a hallmark of cancer and hence characterizing and understanding the epigenetic signatures of cancer cells compared to normal cells at the single-cell level is crucial. Furthermore, the reversible nature of epigenetic alterations provides opp...