Grant ID RP200423
Awarded On February 19, 2020
Title Adipocyte-Producing Noncoding RNA Promotes Liver Cancer Immunoresistance
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Liuqing Yang
Cancer Sites Gallbladder, Liver and Intrahepatic Bile Duct
Contracted Amount $900,000
Lay Summary

Obesity has been established as a risk factor in the development of a multitude of cancer types and causes substantial impairment of anti-tumor immunity. However, the underlying molecule mechanisms remain elusive. Our preliminary data demonstrated that a small nucleolar RNA (snoRNA),SNORD46,is upregulated in liver cancer and negatively correlates with the cytotoxic leukocytes infiltration. Genetic evidence indicated that the expression of SNORD46 leads to obesity and liver tumors resistant to immunotherapy. The goal of this proposal is to comprehensively characterize and implicate SNORD46 as a driver of obesity-associated liver cancer and demonstrate that targeting snoRNAs effectively improv...

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