Grant ID RP200254
Awarded On August 19, 2020
Title Interrogating the Senescence-Associated Secretory Phenotype and its Dependence On the ATM Protein Kinase
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas at Austin
Principal Investigator/Program Director Tanya Paull
Cancer Sites All Sites
Contracted Amount $754,398
Lay Summary

Chemotherapy and radiation are still standard therapies for many cancers and can be very effective in some contexts to block cancer cell growth. These types of acute treatments generate massive DNA damage in exposed tissues which causes cell death and also generates senescence - a state of permanent arrest. Unfortunately, senesence does not just block cancer cell growth but can also induce reprogramming of cellular signaling and metabolism, called the senescence-associated secretory pathway (SASP), that induces inflammation in surrounding tissues. This inflammatory response actually stimulates the growth of neighboring cells and has been shown to promote secondary tumor progression in some m...

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