Grant ID RP200197
Awarded On February 19, 2020
Title Role ofCMPK2 in Liver Inflammation and Hepatocellular Carcinoma
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Shuang Liang
Cancer Sites Gallbladder, Liver and Intrahepatic Bile Duct
Contracted Amount $900,000
Lay Summary

Hepatocellular carcinoma (HCC)—the dominant form of liver cancer with no effective treatment strategies—has become the second leading cause of cancer-related death worldwide. Interestingly, almost all types of HCCs arise in the context of inflammation that is characterized by infiltration of immune cells to the liver where they produce inflammatory mediators to induce fibrosis/cirrhosis and eventually give rise to HCC. Therefore, understanding how inflammation is activated in the liver becomes important for developing effective anti-HCC therapies. Thanks to the close collaboration between clinical oncologists and bench scientists, we now know that activation of an immune sensor—called the NL...

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