|Awarded On||February 19, 2020|
|Title||Tumor-Secreted LIF Activates a Cytokine- Adipose- Hypothalamic Axis to Induce Cancer Cachexia|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Rodney Infante|
|Cancer Sites||Colorectal, Gallbladder, Liver and Intrahepatic Bile Duct, Lung and Bronchus|
Cancer cachexia is a devastating wasting syndrome consisting of significant fat and muscle loss affecting 50% of all cancer patients. It is responsible for 1/3 of all cancer related deaths. Cancer patients with cachexia live half as long as patients with the same cancers without cachexia. These emaciated patients have a poor quality of life which precludes them from receiving standard of care treatments for their respective cancer. Currently there are no effective treatments for this wasting syndrome. Therefore, clinicians often use non-approved medications for cancer cachexia with limited benefit. We therefore sought to better understand how cancers can cause cachexia wasting in orde...