Grant ID RP200021
Awarded On February 19, 2020
Title Optimizing Therapeutic Strategies Against Lung Cancer Using Multimodality Imaging
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas at Dallas
Principal Investigator/Program Director Li Zhang
Cancer Sites Lung and Bronchus
Contracted Amount $900,000
Lay Summary

Despite improved early detection and the use of targeted therapies and immunotherapies, the lung cancer 5-year survival rate remains 10-20% in most countries. Tumor hypoxia, i.e., oxygen deprivation, is an independent marker of poor prognosis in many types of human cancer. Substantial tumor hypoxia exists in non-small cell lung cancer (NSCLC), even in early-stage tumors. NSCLC represents 85-90% of all lung cancer cases. Importantly, recent studies in human patients and mice have shown that NSCLC tumors exhibit elevated oxidative metabolism relative to adjacent normal tissues. Our studies also showed that NSCLC cells have intensified oxygen consumption, as well as elevated synthesis and uptak...

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