|Awarded On||August 21, 2019|
|Title||Radioactive Nanoseeds for Eradicating Glioblastoma without Crossing Blood-Brain Barrier|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas at Arlington|
|Principal Investigator/Program Director||Yaowu Hao|
|Cancer Sites||Brain and Other Nervous System|
The overall goal of this project is to develop a much more efficacious treatment method for glioblastoma (GBM) with significantly reduced side effects. GBM is the most common and most aggressive primary brain tumor. Currently, standard treatment of GBM is based on surgery (if feasible) followed by radiotherapy and chemotherapy. However, because very invasive GBM tumors have finger-like projections into healthy areas, making it impossible to completely remove the tumor by surgery and/or radiotherapy, and the blood-brain barrier prevents chemicals from crossing into the brain, making it difficult to treat the tumor using chemotherapy, the harsh reality for GBM patients is that there is no effe...