|Awarded On||August 21, 2019|
|Title||Targeting ROR-gt:IL-17 pathway to inhibit colon cancer|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Venuprasad K Poojary|
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in both men and women in the United States. This year alone, approximately 150,000 new CRC cases will be diagnosed, and approximately 50,000 people die from CRC every year. In addition to genetic mutations (changes in the DNA), dysregulated inflammation can lead to colon cancer. Recent studies from our lab and other labs show that increased production of interleukin-17 (IL-17), a type of protein produced in response to gut microbes by inflammatory cells promote the growth of colon cancer. Our studies have shown that a protein called ROR-gt is the main factor that induces IL-17 expression in the colon. We have developed new...