|Awarded On||February 21, 2019|
|Title||Comprehensive Evaluation of Functional Enhancers in Breast Cancer Risk Susceptibility Loci|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Gary Hon|
Nearly 15% of American women will be diagnosed with breast cancer in their lifetimes. But the underlying genetic basis for breast cancer risk remains incomplete. What is known is that many women at risk for breast cancer share common changes in their DNA sequence, and that these changes are highly enriched for DNA elements called enhancers. Since enhancers play key roles in regulating the expression of genes, we hypothesize that genetic variation leads to increased breast cancer risk by altering the activity of enhancers, with consequent changes in the expression of cancer-promoting genes. The central obstacle we face today is that the identities of these cancer-promoting enhancers and their...