|Awarded On||February 21, 2019|
|Title||Decoding the Pathogenic Roles of Noncoding Variants in Hematopoietic Malignancies|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Jian Xu|
Acute myeloid leukemia (AML) accounts for 90% of acute leukemias in adult and 15-20% of those in children. AML is a genetically heterogeneous blood cancer associated with a variety of genomic alterations. The discovery of recurrent mutations in protein-coding genes has provided successful targets for diagnosis, prognosis and therapies; however, it remains elusive how alterations within non-coding DNA sequences, consisting of 98.5% of human genome, contribute to AML development. The challenge is twofold: 1) to establish causality of non-coding mutations, and 2) to distinguish oncogenic non-coding drivers from non-functional genetic variants. Enhancers are non-coding DNA sequences that determi...